News-optimism for medicines and amblyopia in adults-perhaps you can 'heal ...
we will be less depressed with prozac and eyes see better ... maybe ...
Prozac: four months of treatment with this drug and returns the view, maybe! Posted by Julian
Medical Research.
Thursday April 24, 2008.
interesting and unexpected discovery came when researchers at the Institute of Neurosciences of the CNR with their colleagues at the Scuola Normale di Pisa, who published the findings of a study in the journal Science.
Subject of work, Fluoxetine, the active ingredient of Prozac, known antidepressant used in recent years more and more to treat depression in young people and especially in the elderly. According to Italian scientists, the discovery of which were added filandosi and English researchers who participated in the study, Prozac, one of the commercial names of the molecule, would have the power to invigorate the brain of the adult, a fact which would regain sight when you are lost because of amblyopia, as demonstrated by experiments on rats that fin'adesso made soon, however, could be exported in humans.
"Prozac, or fluoxetine hydrochloride, commonly known as fluoxetine, is widely used to treat depression, obsessive-compulsive disorders and panic attacks," said Lamberto Maffei, director of the Institute of Neuroscience (In) of the CNR Pisa and professor of neurobiology at the Scuola Normale. "It belongs to the class of selective serotonin reuptake inhibitors (SSRIs) and acts by increasing in the brain levels of serotonin, which is one of the main neurotransmitters in the nervous system. As this action at the level of neural circuits are then translated into the documented efficacy of Prozac is a well-publicized problem. "
One of the most reliable theories about the new feature that Prozac would exercise on the brain is to the effect that the drug stimulates the plasticity of the noble organ, with the result that neurons and connections that are established around these cells, are, after taking the product, more easily able to respond to external stimuli. Until now, experimentally, the evidence of this sort of brain rejuvenation is highlighted in quei ratti affetti da ambliopia, una malattia diffusa anche nell’uomo e che consiste in una sorta di mancata collaborazione dell’occhio destro col sinistro e viceversa a causa del fatto che uno dei due occhi sviluppa un atteggiamento cosiddetto “pigro”, ovvero non segue adeguatamente ciò che fa l’altro ciò determina tutta una serie di disturbi che da adulti diventa difficile curare, atteso che l’affezione colpisce per lo più soggetti molto giovani ed è accompagnato e,a volte preceduto, da patologie quali cataratta congenita, strabismo ed opacizzazioni della cornea.
Ma oggi le cose potrebbero cambiare repentinamente, essendosi visto che nei ratti la condizione patologica migliorava sensibilmente anche in animali adulti giungendo persino ad una remissione totale della sintomatologia, se questi ratti venivano trattati per un mese di seguito con la Fluoxetina.
“La sorprendente capacità della fluoxetina di stimolare la plasticità della corteccia visiva è dovuta all’azione su due principali fattori molecolari”, spiega ancora Maffei. “Da una parte, determina nei ratti la riduzione dei livelli del neurotrasmettitore inibitorio GABA, un fattore molecolare necessario al corretto funzionamento dei centri nervosi, ma ritenuto responsabile anche della perdita di plasticità che si verifica nel cervello adulto. Dall’altra, la riduzione dell’inibizione intracorticale si accompagna all’aumento levels of a neurotrophin, BDNF, which promotes directly the structural changes and functional properties of cortical circuits needed for vision. "
"These results," stressed José Fernando Maya Vetencourt and Alessandro Sale, researchers at the Scuola Normale di Pisa, "help to clarify the mechanisms through which it implements the action of antidepressants, but they suggest the cellular and molecular alterations which could explain a widespread disease such as depression, the precise etiology is still poorly understood. Furthermore, the results of this study pave the way toward new possible applications of fluoxetine in diseases other than related to the treatment of common diseases in the aging brain, like Alzheimer's disease and other syndromes in which excessive intracortical inhibition is considered the base of the malfunction of neural circuits. "
In order to correct information, however, scientists are keen to stress that while it is desirable to use in the treatment of fluoxetine in humans dell'ambliopia tomorrow and other pathologies, such as those previously mentioned, the current state of knowledge is still too early to determine with certainty whether this is easily achievable in humans, due to the fact that in comparison to that of rats, the nervous system dell’uomo è di gran lunga più complesso e complicato.
Ciò non toglie, tuttavia, che nel prossimo periodo gli scienziati siano in grado di rispondere a quest’altro quesito gli si ponga; può la Fluoxetina ridare la vista agli uomani adulti affetti da ambliopia? Vedremo!
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