taken from http://farmacologiaoculare.wordpress.com/2009/01/03/la-stimolazione-farmacologica-dellocchio-ambliope-con-citicolina/ # comment-396
pharmacological stimulation with partially sighted eye Citicolina
3 January 2009 by farmacologiaoculare
The citicolina is a drug widely used in neurology whose protective effects on the membranes of nerve cells have been described in ' article of 24.11.2008
From some years citicolina is used as a neuroprotectant in glaucoma (dedicated to a series of articles on this topic) and as a complementary therapy treatment occlusive nell'ambliopia . A recent article describing the effects of citicolina in this indication can be downloaded from this link .
insufficient foveal stimuli or altered interactions can cause an abnormal binocular visual input during the critical period of development of the vision and then determine an alteration in the genetically programmed process that liquid cell gamglionari retinal axons to the lateral geniculate body and then to the cortex These visual
development process is influenced by both endogenous and exogenous stimuli and therefore could be modulated pharmacologically.
Dopamine is a neurotransmitter important intraretinal used in interneuronal communication between ganglion cells and visual cortex. Alterations in image processing and sensitivity retinal were seen in subjects with deficiency of dopamine (m.'s disease). Therefore, increased concentrations of dopamine in the retina and the higher nerve centers could stop the pathological mechanism that leads to amblyopia, as has been reported by administering the precursor of dopamine (Levo-dihydroxyphenylalanine or levodopa).
citicolina is also able to induce an increased synthesis of some neurotransmitters in some areas of the central nervous system (particularly acetylcholine, dopamine, norepinephrine, serotonin). Choline is the direct precursor of acetylcholine, and this justifies the activity of cholinergic citicolina. The mechanism of increased synthesis of dopamine however, is not fully understood. The main hypothesis is that it stimulated the activity of tyrosine hydroxylase, an enzyme directly involved in the synthesis of dopamine, probably due to increased synthesis of acetylcholine.
stimulation of the dopaminergic system may be a common mechanism that causes both an improvement in motor symptoms in parkinsonian patients that improved sensitivity and retinal nerve conduction along the visual pathways. In keeping with this, there are experimental works that signal an increase in the concentration of dopamine in the retina of animals treated with citicolina. This
dopaminergic-like activity of the rational citicolina gers for use in the treatment dell'ambliopia, similar to those previously observed with levodopa. The goal of treatment is to integrate with citicolina occlusive therapy will reduce the visual input fixer in the eye with a direct pharmacological stimulation of the eye with the less-developed visual . The combined treatment occlusion + citicolina antiabliopica makes it more effective therapy, thus maintaining a more stable improvement in visual acuity over time. The
citicolina can be administered orally, with no significant adverse reaction, up to a dose of 80/mg/kg bw
drawn from blog mentioned above on recovering dell'ambliopia in adulthood (43 years) here are a question and answer
From some years citicolina is used as a neuroprotectant in glaucoma (dedicated to a series of articles on this topic) and as a complementary therapy treatment occlusive nell'ambliopia . A recent article describing the effects of citicolina in this indication can be downloaded from this link .
insufficient foveal stimuli or altered interactions can cause an abnormal binocular visual input during the critical period of development of the vision and then determine an alteration in the genetically programmed process that liquid cell gamglionari retinal axons to the lateral geniculate body and then to the cortex These visual
development process is influenced by both endogenous and exogenous stimuli and therefore could be modulated pharmacologically.
Dopamine is a neurotransmitter important intraretinal used in interneuronal communication between ganglion cells and visual cortex. Alterations in image processing and sensitivity retinal were seen in subjects with deficiency of dopamine (m.'s disease). Therefore, increased concentrations of dopamine in the retina and the higher nerve centers could stop the pathological mechanism that leads to amblyopia, as has been reported by administering the precursor of dopamine (Levo-dihydroxyphenylalanine or levodopa).
citicolina is also able to induce an increased synthesis of some neurotransmitters in some areas of the central nervous system (particularly acetylcholine, dopamine, norepinephrine, serotonin). Choline is the direct precursor of acetylcholine, and this justifies the activity of cholinergic citicolina. The mechanism of increased synthesis of dopamine however, is not fully understood. The main hypothesis is that it stimulated the activity of tyrosine hydroxylase, an enzyme directly involved in the synthesis of dopamine, probably due to increased synthesis of acetylcholine.
stimulation of the dopaminergic system may be a common mechanism that causes both an improvement in motor symptoms in parkinsonian patients that improved sensitivity and retinal nerve conduction along the visual pathways. In keeping with this, there are experimental works that signal an increase in the concentration of dopamine in the retina of animals treated with citicolina. This
dopaminergic-like activity of the rational citicolina gers for use in the treatment dell'ambliopia, similar to those previously observed with levodopa. The goal of treatment is to integrate with citicolina occlusive therapy will reduce the visual input fixer in the eye with a direct pharmacological stimulation of the eye with the less-developed visual . The combined treatment occlusion + citicolina antiabliopica makes it more effective therapy, thus maintaining a more stable improvement in visual acuity over time. The
citicolina can be administered orally, with no significant adverse reaction, up to a dose of 80/mg/kg bw
drawn from blog mentioned above on recovering dell'ambliopia in adulthood (43 years) here are a question and answer
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